Volume 16, Issue 3 - September 2016


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Revista de Gestão Costeira Integrada
Volume 16, Issue 3, September 2016, Pages 299-326

DOI: 10.5894/rgci669
* Submission: 29 JAN 2016; Peer review: 11 MAR 2016; Revised: 16 JUL 2016; Accepted: 10 AUG 2016; Available on-line: 26 SEP 2016

Endocrine disruptors: strategies for determination and occurrence in marine environments *  

Gabriel Cotrima, @, Cristiane S. Fahningb, Gisele O. da Rochaa,b,c,d, Vanessa Hatjea,b,c,d

@sup> Corresponding author: [email protected]
a - Centro Interdisciplinar em Energia e Ambiente – CIEnAm, UFBA, 40170-290, Salvador-BA, Brazil
b - Instituto de Química, Universidade Federal da Bahia, 40170290, Salvador-BA, Brazil
c - INCT de Energia e Ambiente, UFBA, 40170-290, Salvador-BA, Brazil
d - INCT de Ambientes Marinhos Tropicais, UFBA, 40170-290, Salvador-BA, Brazil

Research examining the occurrence of endocrine disruptors (ED) in the marine environment has substantially increased. These contaminants have been observed in several environmental compartments and matrices, and they may cause severe adverse effects in humans and ecosystems. In this study more than 240 papers investigating the analytical developments regarding the analysis on ED in environmental matrices and the occurrence of these compounds were critically evaluated. Modern sample preparation procedures aiming the use of minimal sample manipulation, minimal amount of solvents and energy according to the Green Chemistry principles are widely used. The ED in marine environments occurs in trace concentrations and their quantification still represents a challenge. The effects of these contaminants in marine ecosystems are poorly understood. However, due to their large use, it is predicted that new analytical developments to deal with ED contamination will promote a large increase in the number of scientific publications in the near future. Regulations and mitigation measures for the presence of these contaminants in the environment are still scarce and need to be quickly implemented to reduce potential future adverse effects on ecosystem services of coastal environments.

Keywords: Emerging contaminants; Endocrine disrupters; Contamination; Sample preparation; Environmental analysis


Pesquisas que examinam a ocorrência de interferentes endócrinos (IE) no ambiente marinho têm aumentado substancialmente. Estes contaminantes podem causar efeitos adversos em seres humanos e nos ecossistemas e têm sido observados em vários compartimentos e matrizes ambientais. Neste estudo, mais de 240 trabalhos que relataram o desenvolvimento analítico de IE em diversas matrizes e a ocorrência destes compostos no ambiente marinho foram criticamente avaliados. Procedimentos de preparo de amostra, visando a mínima manipulação, a mínima quantidade de solventes e energia de acordo com os princípios de Química Verde estão sendo amplamente utilizados. Os IE em ambientes marinhos ocorrem em concentrações traço e sua quantificação ainda representa um grande desafio. Como resultado, os efeitos desses contaminantes em ecossistemas marinhos ainda são mal compreendidos. No entanto, devido ao amplo uso destes compostos é previsto que novos desenvolvimentos analíticos para a determinação de IE irão promover um grande aumento no número de publicações científicas no futuro. Regulações e medidas mitigadoras para a ocorrência destes contaminantes ainda são bastante reduzida e precisam ser rapidamente implementadas para reduzir os futuros potenciais efeitos adversos nos serviços ecossistêmicos dos ecossistemas costeiros.

Palavras-chave: ???


Agência Nacional de Vigilância Sanitária (ANVISA); Resolução RE nº 41, 2011.

Aksglaede, L.; Juul, A.; Leffers, H.; Skakkebaek, N. E.; Andersson, A. M. (2006) - The sensitivity of the child to sex steroids: possible impact of exogenous estrogens. Human Reproduction Update, 12(4):341-349. DOI:10.1093/humupd/dml018

Ammann, A. A.; Macikova, P.; Groh, K. J.; Schirmer, K.; Suter, M. J. F. (2014) - LC-MS/MS determination of potential endocrine disruptors of cortico signalling in rivers and wastewaters. Analytical and Bioanalytical Chemistry, 406(29):7653–7665. DOI: 10.1007/s00216-014-8206-9

Anezaki, K.; Nakano, T. (2015) - Unintentional PCB in chlorophenylsilanes as a source of contamination in environmental samples. Journal of Hazardous Materials, 287:111–7. DOI:10.1016/j.jhazmat.2015.01.026

Antizar-Ladislao, B. (2009) - Polycyclic aromatic hydrocarbons, polychlorinated biphenyls, phthalates and organotins in northern Atlantic Spain’s coastal marine sediments. Journal of Environmental Monitoring, 11(1):85-91. DOI: 10.1039/b808668k

Anumol, T.; Snyder, S. A. (2015) - Rapid analysis of trace organic compounds in water by automated online solid-phase extraction coupled to liquid chromatography–tandem mass spectrometry. Talanta, 132: 77–86. DOI:10.1016/j.talanta.2014.08.011

Arditsoglou, A.; Voutsa, D. (2008a) - Determination of Phenolic and Steroid Endocrine Disrupting Compounds in Environmental Matrices. Environmental Science and Pollution Research, 15(3):228-236. DOI: 10.1065/espr2007.12.459

Arditsoglou, A., Voutsa, D. (2008b) - Passive sampling of selected endocrine disrupting compounds using polar organic chemical integrative samplers. Environmental Pollution, 156:316–324. DOI:10.1016/j.envpol.2008.02.007

Arditsoglou, A.; Voutsa, D. (2012) - Occurrence and partitioning of endocrine-disrupting compounds in the marine environment of Thermaikos Gulf, Northern Aegean Sea, Greece. Marine Pollution Bulletin, 64(11):2443-2452. DOI: 10.1016/j.marpolbul.2012.07.048

Assunção, J. V. de; Pesquero, C. R. (1999) - Dioxinas e furanos: origens e riscos. Revista de Saúde Pública, 33(5):523-530. DOI: 10.1590/S0034-89101999000500014

Bach, C.; Dauchy, X.; Chagnon, M.-C.; Etienne, S. (2012) - Chemical compounds and toxicological assessments of drinking water stored in polyethylene terephthalate (PET) bottles: A source of controversy reviewed. Water Research, 46(3):571-583. DOI:10.1016/j.watres.2011.11.062

Bartolomé, L.; Etxebarria, N.; Martínez-Arkarazo, I.; Raposo, J. C.; Usobiaga, A.; Zuloaga, O.; Raingerard, D.; Ortiz-Zarragoitia, M.; Cajaraville, M. P. (2010) - Distribution of organic microcontaminants, butyltins, amd metals in mussels from the estuary of Bilbao. Archives of Environmental Contamination and Toxicology, 59:244-254. DOI: 10.1007/s00244-009-9458-9

Basheer, C.; Lee, H. K.; Tan, K. S. (2004) - Endocrine disrupting alkylphenols and bisphenol-A in coastal waters and supermarket seafood from Singapore. Marine Pollution Bulletin, 48 (11-12):1161-1167. DOI: 10.1016/j.marpolbul.2004.04.009

Bayat, J.; Hashemi, S. H.; Khoshbakht, K.; Deihimfard, R.; Shahbazi, A.; Momeni-Vesalian, R. (2015). Monitoring of polycyclic aromatic hydrocarbons on agricultural lands surrounding Tehran oil refinery. Environmental Monitoring and Assessment, 187(7):451. DOI:10.1007/s10661-015-4646-8

Beausse, J. (2004) - Selected drugs in solid matrices: A review of environmental determination, occurrence and properties of principal substances. Trends in Analytical Chemistry, 23:753-761. DOI:10.1016/j.trac.2004.08.005

Beck, I.-C.; Bruhn, R.; Gandrass, J.; Ruck, W. (2005) - Liquid chromatography–tandem mass spectrometry analysis of estrogenic compounds in coastal surface water of the Baltic Sea. Journal of Chromatography A, 1090(1-2):98-106. DOI: 10.1016/j.chroma.2005.07.013

Bedia, C.; Dalmau, N.; Jaumot, J.; Tauler, R. (2015) - Phenotypic malignant changes and untargeted lipidomic analysis of long-term exposed prostate cancer cells to endocrine disruptors. Environmental Research, 140:18–31. DOI:10.1016/j.envres.2015.03.014

Behera, S. K.; Kim, H. W.; Oh, J.-E.; Park, H.-S. (2011) - Occurrence and removal of antibiotics, hormones and several other pharmaceuticals in wastewater treatment plants of the largest industrial city of Korea. Science of the Total Environment, 409(20):4351-4360. DOI:10.1016/j.scitotenv.2011.07.015

Belfroid, A. C.; Van der Horst, A.; Vethaak, A. D.; Schäfer, A. J.; Rijs, G. B.; Wegener, J.; Cofino, W. P. (1999) - Analysis and occurrence of estrogenic hormones and their glucuronides in surface water and waste water in The Netherlands. Science of the Total Environment, 225(1-2):101-108. DOI: 10.1016/S0048-9697(98)00336-2

Benjamin, S.; Pradeep, S.; Josh, M. S.; Kumar, S. (2015) - A monograph on the remediation of hazardous phthalates. Journal of Hazardous Materials, 298:58-72. DOI: 10.1016/j.jhazmat.2015.05.004

Bergé, A.; Gasperi, J.; Rocher, V.; Gras, L.; Coursimault, A.; Moilleron, R. (2014). Phthalates and alkylphenols in industrial and domestic effluents: case of Paris conurbation (France). The Science of the Total Environment, 488-489(2014):26–35. DOI:10.1016/j.scitotenv.2014.04.081

Bertin, A.; Inostroza, P. A.; Quiñones, R. A. (2011) - Estrogen pollution in a highly productive ecosystem off central-south Chile. Marine Pollution Bulletin, 62 (7):1530-1537. DOI:10.1016/j.marpolbul.2011.04.002

Bhandari, A.; Surampalli, R. Y.; Adams, C. D.; Champagne, P.; Ong, S. K.; Tyagi, R. D.; Zhang, T. C. (2009) - Contaminants of Emerging Environmental Concern. 496p., American Society of Civil Engineers; Reston: Virginia, USA. ISBN: 0784472661, 9780784472668.

Bian, H.; Li, Z.; Liu, P.; Pan, J. (2010) - Spatial distribution and deposition history of nonylphenol and bisphenol A in sediments from the Changjiang River (Yangtze River) Estuary and its adjacent East China Sea. Acta Oceanologica Sinica, 29(5):44-51. DOI: 10.1007/s13131-010-0062-7

Birch, G. F.; Drage, D. S.; Thompson, K.; Eaglesham, G.; Mueller, J. F. (2015). Emerging contaminants (pharmaceuticals, personal care products, a food additive and pesticides) in waters of Sydney estuary, Australia. Marine Pollution Bulletin, 97(1-2):56–66. DOI: 10.1016/j.marpolbul.2015.06.038

Birkett, J. W.; Lester, J. N. (2003) - Endocrine Disrupters in Wastewater and Sludge Treatment Processes. 285p., CRC Press LLC: Londres, Inglaterra. ISBN: 9781566706018 - CAT# L1601

Boisen, K. A.; Chellakooty, M.; Schmidt, I. M.; Kai, C. M.; Damgaard, I. N.; Suomi, A.-M.; Toppari, J.; Skakkebaek, N. E.; Main, K. M. (2005) - Hypospadias in a Cohort of 1072 Danish Newborn Boys: Prevalence and Relationship to Placental Weight, Anthropometrical Measurements at Birth, and Reproductive Hormone Levels at Three Months of Age. The Journal of Clinical Endocrinology & Metabolism, 90(7):4041-4046. DOI: 10.1210/jc.2005-0302

Boitsov, S.; Mjøs, S. A.; Meier, S. (2007) - Identification of estrogen-like alkylphenols in produced water from offshore oil installations. Marine Environmental Research, 64(5):651-665. DOI:10.1016/j.marenvres.2007.07.001

Bossio, J. P.; Harry, J.; Kinney, C. (2008) - Application of ultrasonic assisted extraction of chemically diverse organic compounds from soils and sediments. Chemosphere, 70(5):858-864. DOI:10.1016/j.chemosphere.2007.06.088

Bouzas, A.; Aguado, D.; Martí, N.; Pastor, J. M.; Herráez, R.; Campins, P.; Seco, A. (2011) - Alkylphenols and polycyclic aromatic hydrocarbons in eastern Mediterranean Spanish coastal marine bivalves. Environmental Monitoring and Assessment, 176:169-181. DOI: 10.1007/s10661-010-1574-5

Bovee, T. F. H.; Helsdingen, R. J. R.; Rietjens, I. M. C. M.; Keijer, J.; Hoogenboom, R. L. A. P. (2004) - Rapid yeast estrogen bioassays stably expressing human estrogen receptors α and β, and green fluorescent protein: a comparison of different compounds with both receptor types. Journal of Steroid Biochemistry & Molecular Biology, 91(3):99-109. DOI: 10.1016/j.jsbmb.2004.03.118

Bowman, J. C.; Readman, J. W.; Zhou, J. L. (2003) - Sorptionof the natural endocrine disruptors, oestrone and 17β-oestradiol in the aquatic environment. Environmental Geochemistry and Health, 2, 25(1):63-67. DOI: 10.1023/A:1021296831175

Boyle, A. W.; Silvin, C. J.; Hassett, J. P.; Nakas, J. P.; Tanenbaum, S. W. (1992) - Bacterial PCB biodegradation. Biodegradation, 3(2):285-298. DOI: 10.1007/BF00129089

Braga, O.; Smythe, G.; Schäfer, I.; Feitz, J. (2005) - Steroid estrogens in ocean sediments. Chemosphere, 61(6) 827-833. DOI: 10.1016/j.chemosphere.2005.04.053

Bulayeva, N. N.; Watson, C. S. (2004) - Xenoestrogen-Induced ERK-1 and ERK-2 Activation via Multiple Membrane-Initiated Signaling Pathways. Environmental Health Perspectives, 112(15):1481-1487. DOI: 10.1289/ehp.7175

Buttke, D. E.; Sircar, K.; Martin, C. (2012) - Exposures to Endocrine-Disrupting Chemicals and Age of Menarche in Adolescent Girls in NHANES (2003 – 2008). Environmental Health Perspectives, 120(11):1613. DOI: 10.1289/ehp.1104748

Cai, M.; Yang, H.; Xie, Z.; Zhao, Z.; Wang, F.; Lu, Z.; Sturm, R.; Ebinghaus, R. (2012a) - Per- and polyfluoroalkyl substances in snow, lake, surface runoff water and coastal seawater in Fildes Peninsula, King George Island, Antarctica. Journal of Hazardous Materials, 209-210:335–342. DOI:10.1016/j.jhazmat.2012.01.030

Cai, M.; Zhao, Z.; Yang, H.; Yin, Z.; Hong, Q.; Sturm, R.; Ebinghaus, R.; Ahrens, L.; Cai, M.; He, J.; Xie, Z. (2012b) - Spatial distribution of per- and polyfluoroalkyl compounds in coastal waters from the East to South China Sea. Environmental Pollution, 161:162–169. DOI:10.1016/j.envpol.2011.09.045

Carpenter, D. O. (2006) - Polychlorinated Biphenyls (PCBs): Routes of Exposure and Effects on Human Health. Reviews on Environmental Health, 21(1):1-23. DOI: 10.1515/REVEH.2006.21.1.1

Casatta, N.; Mascolo, G.; Roscioli, C.; Vigano, L. (2015) - Tracing endocrine disrupting chemicals in a coastal lagoon (Sacca di Goro, Italy): Sediment contamination and bioaccumulation in Manila clams. Science of the Total Environment, 511:214-222. DOI: 10.1016/j.scitotenv.2014.12.051

Čeh, K.; Majdič, G. (2010) - Pesticides as endocrine disruptors. Slovenian Veterinary Research, 47, 163. ISSN 1580-4003. Ljubljana, Slovenia. Available:

Cheng, C.-Y.; Liu, L.-L.; Ding, W.-H. (2006) - Occurrence and seasonal variation of alkylphenols in marine organisms from the coast of Taiwan. Chemosphere, 65(11):2152-2159. DOI:10.1016/j.chemosphere.2006.06.017

Cheng, Z.; Nie, X.P.; Wang, H. P.; Wong, M. H. (2013) - Risk assessments of human exposure to bioaccessible phthalate esters through market fish consumption. Environment International, 57-58, 75-80.  DOI: 10.1016/j.envint.2013.04.005.

Christiansen, S.; Kortenkamp, A.; Axelstad, M.; Boberg, J.; Scholze, M.; Jacobsen, P. R.; Faust, M.; Lichtensteiger, W.; Schlumpf, M.; Burdorf, A.; Hass, U. (2012) - Mixtures of endocrine disrupting contaminants modelled on human high end exposures: an exploratory study in rats. International journal of andrology, 35(3):303-316. DOI: 10.1111/j.1365-2605.2011.01242.x

Clapauch, R.; Meirelles, R. M. R.; Julião, M. A. S. G.; Loureiro, C. K. C.; Giarodoli, P. B.; Pinheiro, S. A.; Harrigan, A. R.; Spritzer, P. M.; Pardini, D. P.; Weiss, R. V.; Athayde, A.; Russo, L. A.; Póvoa, L. C. (2002) - Fitoestrogênios: Posicionamento do departamento de endocrinologia feminina da sociedade brasileira de endocrinologia e metabologia (SBEM). Arquivos Brasileiros de Endocrinologia e Metabologia, 46(6):679-695. DOI: 10.1590/S0004-27302002000600013

Colin, N.; Porte, C.; Fernandes, D.; Barata, C.; Padrós, F.; Carrassón. M.; Monroy, M.; Cano-Rocabayera, O.; Sostoa, A.; Piña, B.; Maceda-Veiga, A. (2016) - Ecological relevance of biomarkers in monitoring studies of macro-vertebrates and fish in Mediterranean rivers. Science of the Total Environment, 540:307-323. DOI: 10.1016/j.scitotenv.2015.06.099

Colón, I.; Doris, C.; Bourdony, C. J.; Rosario, O. (2000) - Identification of pthalate esters in girls with premature breast development. Environmental Health Perspectives, 108(9):895-900. DOI: 10.1289/ehp.00108895

Cunha, B. B.; Botero, W. G.; Oliveira, L. C.; Carlos, V. M.; Pompêo, M. L. M.; Fraceto, L. F.; Rosa, A. H. (2012) - Kinetics and Adsorption Isotherms of Bisphenol A, Estrone, 17β-Estradiol, and 17α-Ethinylestradiol in Tropical Sediment Samples. Water, Air, & Soil Pollution, 223(1):329-336. DOI: 10.1007/s11270-011-0861-2

D’Ascenzo, G.; Di Corcia, A.; Gentili, A.; Mancini, R.; Mastropasqua, R.; Nazzari, M.; Samperi, R. (2003) - Fate of natural estrogen conjugates in municipal sewage transport and treatment facilities. Science of the Total Environment, 302(1-3):199-209. DOI: 10.1016/S0048-9697(02)00342-X

Da Rocha, G. O.; Lopes, W. A.; Pereira, P. A. D. P.; Vasconcellos, P. de C.; Oliveira, F. S.; Carvalho, L. S.; Conceição, L. dos S.; Andrade, J. B. D. (2009) - Quantification and Source Identification of Atmospheric Particulate Polycyclic Aromatic Hydrocarbons and their Dry Deposition Fluxes at Three Sites in Salvador Basin, Brazil, Impacted by Mobile and Stationary Sources. Journal of the Brazilian Chemical Society, 20(4):680-692. DOI: 10.1590/S0103-50532009000400012

Dargnat, C.; Teil, M.-J.; Chevreuil, M.; Blanchard, M. (2009) - Phthalate removal throughout wastewater treatment plant Case study of Marne Aval station (France). Science of the Total Environment, 407(4):1235-1244. DOI: 10.1016/j.scitotenv.2008.10.027.

Darnerud, P. O. (2008) - Brominated flame retardants as possible endocrine disrupters. International journal of andrology, 31(2):152-160. DOI: 10.1111/j.1365-2605.2008.00869.x.

David, A.; Fenet, H.; Gomez, E. (2009) - Alkylphenols in marine environments: Distribution monitoring strategies and detection considerations. Marine Pollution Bulletin, 58(7):953-960. DOI:10.1016/j.marpolbul.2009.04.021

De la Cruz, N.; Giménez, J.; Esplugas, S.; Grandjean, D.; de Alencastro, L. F.; Pulgarín, C. (2012) - Degradation of 32 emergent contaminants by UV and neutral photo-fenton in domestic wastewater effluent previously treated by activated sludge. Water research, 46(6):1947-1957. DOI: 10.1016/j.watres.2012.01.014

De los Ríos, A.; Juanes, J.; Ortiz-Zarragoitia, M.; López de Alda, M.; Barceló, D.; Cajaraville, M. P. (2012) - Assessment of the effects of a marine urban outfall discharge on caged mussels using chemical and biomarker analysis. Marine Pollution Bulletin, 64(3):563-573. DOI:10.1016/j.marpolbul.2011.12.018

Deblonde, T.; Cossu-leguille, C.; Hartemann, P. (2011) - Emerging pollutants in wastewater: A review of the literature. The International Journal of Hygiene and Environmental Health, 214:442–448. DOI:10.1016/j.ijheh.2011.08.002

Dévier, M.-H., Labadie, P., Togola, A., Budzinski, H. (2010). Simple methodology coupling microwave-assisted extraction to SPE/GC/MS for the analysis of natural steroids in biological tissues: application to the monitoring of endogenous steroids in marine mussels Mytilus sp. Analytica Chimica Acta, 657(1):28–35. DOI: 10.1016/j.aca.2009.10.023

Diamanti-Kandarakis, E.; Bourguignon, J.-P.; Giudice, L. C.; Hauser, R.; Prins, G. S.; Soto, A. M.; Zoeller, R. T.; Gore, A. C. (2009) - Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement. Endocrine Reviews, 30(4): 293-342. DOI: 10.1210/er.2009-0002

Diehl, J.; Johnson, S. E.; Xia, K.; West, A.; Tomanek, L. (2012) - The distribution of 4-nonylphenol in marine organisms of North American Pacific Coast estuaries. Chemosphere, 87(5):490-497. DOI:10.1016/j.chemosphere.2011.12.040

Dodds, E. C.; Lawson, W. (1936) - Synthetic OEstrogenic Agents without the Phenanthrene Nucleus. Nature, 137(3476): 996. DOI: 10.1038/137996a0

Dodds, E. C.; Lawson, W. (1938) - Molecular Structure in Relation to Oestrogenic Activity. Compounds without a Phenanthrene Nucleus. Proceedings of the Royal Society B, 125(839):222-232. DOI: 10.1098/rspb.1938.0023

Duan, X.; Li, Y.; Li, X.; Zhang, D.; Gao, Y. (2014) - Alkylphenols in surface sediments of the Yellow Sea and East China Sea inner shelf: Occurrence, distribution and fate. Chemosphere, 107: 265–273. DOI: 10.1016/j.chemosphere.2013.12.054

Dzieweczynski, T. L.; Buckman, M. C. (2013) - Acute exposure to 17α-ethinylestradiol disrupts audience effects on male–male interactions in Siamese fighting fish, Betta splendens. Hormones and Behavior, 63(3):497-502. DOI: 10.1016/j.yhbeh.2013.01.002

Ebinghaus, R.; Xie, Z. (2006) - Occurrence and air sea-exchange of novel organic pollutants in the marine environment. Journal de Physique IV, 139:211-237 DOI: 10.1051/jp4:2006139016

Emnet, P., Gaw, S., Northcott, G., Storey, B., Graham, L. (2015). Personal care products and steroid hormones in the Antarctic coastal environment associated with two Antarctic research stations, McMurdo Station and Scott Base. Environmental Research, 136:331–342. DOI:10.1016/j.envres.2014.10.019

EPA (1997) - Special Report on Environmental Endocrine Disruption: An Effects Assessment and Analysis. Environmental Protection Agency, US EPA/630/R-96/012, February 1997.

Eriksson, P.; Jakobsson, E.; Fredriksson, A. (2001) - Brominated Flame Retardants: A Novel Class of Developmental Neurotoxicants in Our Environment? Environmental Health Perspectives, 109(9):903-908. DOI: 10.1289/ehp.01109903

Esteban, S.; Moreno-Merino, L.; Matellanes, R.; Catalá, M.; Gorga, M.; Petrovic, M.; Lopez de Alda, M.; Barceló, D.; Silva, A.; Duran, J. J.;Lopez-Martinez, J.; Valcarcel, Y. (2016) - Presence of endocrine disruptors in freshwater in the northern Antarctic Peninsula region. Environmental Research, 147:179-192. DOI: 10.1016/j.envres.2016.01.034.

Farajzadeh, M. A.; Nouri, N.; Khorram, P. (2014) - Derivatization and microextraction methods for determination of organic compounds by gas chromatography. Trends in Analytical Chemistry, 55:14-23. DOI: 10.1016/j.trac.2013.11.006

Farré, M.; Kantiani, L.; Petrovic, M.; Pérez, S.; Barceló, D. (2012) - Achievements and future trends in the analysis of emerging organic contaminants in environmental samples by mass spectrometry and bioanalytical techniques. Journal of Chromatography A, 1259:86-99. DOI: 10.1016/j.chroma.2012.07.024

Farré, M.; Pérez, S.; Gonçalves, C.; Alpendurada, M. F.; Barceló, D. (2010) - Green analytical chemistry in the determination of organic pollutants in the aquatic environment. Trends in Analytical Chemistry, 29(11):1347-1362. DOI: 10.1016/j.trac.2010.07.016

Fasano, E.; Bono-Blay, F.; Cirillo, T.; Montuori, P.; Lacorte, S. (2012) - Migration of phthalates, alkylphenols, bisphenol A and di(2-ethylhexyl)adipate from food packaging. Food Control, 27(1): 132-138. DOI: 10.1016/j.foodcont.2012.03.005

Fatoki, O. S.; Noma, A. (2001) - Determination of Phthalate Esters in the Aquatic Environment. South African Journal of Chemistry, 54: 69-83. ISSN: 0379-4350, South African. Available:

Ferguson, P. L.; Iden, C. R.; Brownawell, B. J. (2000) - Analysis of alkylphenol ethoxylate metabolites in the aquatic environment using liquid chromatography-electrospray mass spectrometry. Analytical Chemistry, 72(18):4322–4330. DOI: 10.1021/ac000342n

Ferguson, P. L.; Iden, C. R.; Brownawell, B. J. (2001) - Distribution and Fate of Neutral Alkylphenol Ethoxylate Metabolites in a Sewage-Impacted Urban Estuary. Environmental Science & Technology, 35(12):2428-2435. DOI: 10.1021/es001871b

Ferrara, F.; Ademollo, N.; Delise, M.; Fabietti, F.; Funari, E. (2008) - Alkylphenols and their ethoxylates in seafood from the Tyrrhenian Sea. Chemosphere, 72(9):1279–1285. DOI: 10.1016/j.chemosphere.2008.04.060

Fisher, M. M.; Eugster, E. A. (2014) - What is in our environment that effects puberty? Reproductive Toxicology, 44:7-14. DOI: 10.1016/j.reprotox.2013.03.012.

Foster, P. M. D. (2006) - Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters. International Journal of Andrology, 29(1):140–147.

Foster, P. M.; Mylchreest, E.; Gaido, K. W.; Sar, M. (2001) - Effects of phthalate esters on the developing reproductive tract of male rats. Human Reproduction Update, 7:231–235. DOI:10.1093/humupd/7.3.231

Fromme, H.; Teitelbaum, S. L.; Pinney, S. M.; Windham, G.; Liao, L.; Biro, F.; Kushi, L. H.; Erdmann, C.; Hiatt, R. A.; Rybak, M. E.; Calafat, A. M. (2002) - Occurrence of phthalates and bisphenol A and F in the environment. Water Research, 36(6):1429–1438. DOI: 10.1016/S0043-1354(01)00367-0

Frye, C. A.; Bo, E.; Calamandrei, G.; Calzà, L.; Dessì-fulgheri, F.; Fernández, M.; Fusani, L.; Kah, O.; Kajta, M.; Le Page, Y.; Patisaul, H. B.; Venerosi, A.; Wojtowicz, A. K.; Panzica, G. C. (2011) -Endocrine disrupters: a review of some sources, effects, and mechanisms of actions on behaviour and neuroendocrine systems. Journal of Neuroendocrinology, 24(1):144–159. DOI: 10.1111/j.1365-2826.2011.02229.x

Fu, M.; Li, Z.; Gao, H. (2007) - Distribution characteristics of nonylphenol in Jiaozhou Bay of Qingdao and its adjacent rivers. Chemosphere, 69(7):1009–1016. DOI: 10.1016/j.chemosphere.2007.04.061

Funakoshi, G.; Kasuya, S. (2009) - Influence of an estuary dam on the dynamics of bisphenol A and alkylphenols. Chemosphere, 75(4):491–497. DOI: 10.1016/j.chemosphere.2008.12.050.

Gagné, F.; Blaise, C.; Pellerin, J.; Gauthier-Clerc, S. (2002) - Alteration of the biochemical properties of female gonads and vitellins in the clam Mya arenaria at contaminated sites in the Saguenay Fjord. Marine Environmental Research, 53(3):295–310. DOI: 10.1016/S0141-1136(01)00122-2

Garcia-Jares, C.; Regueiro, J.; Barro, R.; Dagnac, T.; Llompart, M. (2009) - Analysis of industrial contaminants in indoor air. Part 2. Emergent contaminants and pesticides. Journal of Chromatography A,1216(3):567–597. DOI: 10.1016/j.chroma.2008.10.020

Gärtner, S.; Balski, M.; Koch, M.; Nehls, I. (2009) - Analysis and migration of phthalates in infant food packed in recycled paperboard. Journal of Agricultural and Food Chemistry, 57(22):10675–10681. DOI: 10.1021/jf902683m

Gavala, H. N.; Alatriste-Mondragon, F.; Iranpour, R.; Ahring, B. K. (2003) - Biodegradation of phthalate esters during the mesophilic anaerobic digestion of sludge. Chemosphere, 52(10):673–682. DOI: 10.1016/S0045-6535(03)00126-7

Gavrilescu, M.; Demnerová, K.; Aamand, J.; Agathos, S.; Fava, F. (2015) - Emerging pollutants in the environment: Present and future challenges in biomonitoring, ecological risks and bioremediation. New Biotechnology, 32:147–156. DOI:10.1016/j.nbt.2014.01.001

Gereckea, A. C.; Schmid, P.; Bogdal, C.; Kohler, M.; Zennegg, M.; Heeb, N. V. (2008) - Brominated Flame Retardants – Endocrine-Disrupting Chemicals in the Swiss Environment. Chimia, 62(6):352-357. DOI: 10.2533/chimia.2008.352

Ghiselli, G.; Jardim, W. F. (2007) - Interferentes endócrinos no ambiente. Quimíca Nova, 30(3):695-706. DOI: 10.1590/S0100-40422007000300032

Gómez-Hens, A.; Aguilar-Caballos, M. (2003) - Social and economic interest in the control of phthalic acid esters. Trends in Analytical Chemistry, 22(11):847–857. DOI: 10.1016/S0165-9936(03)01201-9

Grassi, M.; Rizzo, L.; Farina, A. (2013) - Endocrine disruptors compounds, pharmaceuticals and personal care products in urban wastewater: implications for agricultural reuse and their removal by adsorption process. Environmental Science and Pollution Research, 20(6):3616- 3628. DOI: 10.1007/s11356-013-1636-7.

Gray, L. E.; Wilson, V. S.; Stoker, T.; Lambright, C.; Furr, J.; Noriega, N.; Howdeshell, K.; Ankley, G. T.; Guillette, L. (2006) - Adverse effects of environmental antiandrogens and androgens on reproductive development in mammals. International Journal of Andrology, 29(1):96-104. DOI: 10.1111/j.1365-2605.2005.00636.x

Grigoriadou, A.; Schwarzbauer, J.; Georgakopoulos, A. (2008) - Molecular indicators for pollution source identification in marine and terrestrial water of the industrial area of Kavala city, North Greece. Environmental Pollution, 151(1):231–242. DOI: 10.1016/j.envpol.2007.01.053

Grist, E. P. M.; Wells, N. C.; Whitehouse, P.; Brighty, G.; Crane, M. (2003) - Estimating the effects of 17alpha-ethinylestradiol on populations of the fathead minnow Pimephales promelas: are conventional toxicological endpoints adequate? Environmental Science & Technology, 37(8):1609–1616. DOI: 10.1021/es020086r

Gu, Y.; Yu, J.; Hu, X.; Yin, D. (2016) - Characteristics of the alkylphenol and bisphenol A distributions in marine organisms and implications for human health: A case study of the East China Sea. Science of the Total Environment, 539:460-469. DOI: 10.1016/j.scitotenv.2015.09.011.

Hampl, R.; Kubátová, J.; Stárka, L. (2016) - Steroids and endocrine disruptors—History, recent state of art and open questions. The Journal of Steroid Biochemistry and Molecular Biology, 155(Part B): 217-223.  DOI: 10.1016/j.jsbmb.2014.04.013.

Hashimoto, S.; Ueda, Y.; Kurihara, R.; Shiraishi, F. (2007) - Comparison of the estrogenic activities of seawater extracts from Suruga Bay, Japan, based on chemical analysis or bioassay. Environmental Toxicology and Chemistry, 26(2):279–286. DOI: 10.1897/05-689R1.1

Hashimoto, Y.; Kawaguchi, M.; Miyazaki, K.; Nakamura, M. (2003) - Estrogenic activity of tissue conditioners in vitro. Dental Materials, 19(4):341-346. DOI:10.1016/S0109-5641(02)00064-7

Hassanzadeh, N.; Esmaili Sari, A.; Khodabandeh, S.; Bahramifar, N. (2014) - Occurrence and distribution of two phthalate esters in the sediments of the Anzali wetlands on the coast of the Caspian Sea (Iran). Marine Pollution Bulletin, 89(1-2):128–135. DOI: 10.1016/j.marpolbul.2014.10.017

Heemken, O. P.; Reincke, H.; Stachel, B.; Theobald, N. (2001) - The occurrence of xenoestrogens in the Elbe river and the North Sea. Chemosphere, 45(3):245–259. DOI:10.1016/S0045-6535(00)00570-1

Herrera-Herrera, A. V.; Asensio-Ramos, M.; Hernández-Borges, J.; Rodríguez-Delgado, M. Á. (2010) - Dispersive liquid-liquid microextraction for determination of organic analytes. Trends in Analytical Chemistry, 29 (7):728-751. DOI: 10.1016/j.trac.2010.03.016

Heudorf, U.; Mersch-Sundermann, V.; Angerer, J. (2007) - Phthalates: toxicology and exposure. International Journal of Hygiene and Environmental Health, 210(5):623-634. DOI: 10.1016/j.ijheh.2007.07.011

Hirai, N.; Nanba, A.; Koshio, M.; Kondo, T.; Morita, M.; Tatarazako, N. (2006) - Feminization of Japanese medaka (Oryzias latipes) exposed to 17 beta-estradiol: Effect of exposure period on spawning performance in sex-transformed females. Aquatic Toxicology, 79(3):288–295. DOI: 10.1016/j.aquatox.2006.06.018

Horn, O.; Nalli, S.; Cooper, D.; Nicell, J. (2004) - Plasticizer metabolites in the environment. Water Research, 38(17):3693–3698. DOI: 10.1016/j.watres.2004.06.012

Hotta, Y.; Hosoda, A.; Sano, F.; Wakayama, M.; Niwa, K.; Yoshikawa, H.; Tamura, H. (2010) - Ecotoxicity by the biodegradation of alkylphenol polyethoxylates depends on the effect of trace elements. Journal of Agricultural and Food Chemistry, 58(2):1062–1067. DOI: 10.1021/jf902772m

Huerta, B., Jakimska, A., Llorca, M., Ruhí, A., Margoutidis, G., Acuña, V., Sabater, S. (2015). Development of an extraction and purification method for the determination of multi-class pharmaceuticals and endocrine disruptors in freshwater invertebrates, Talanta, 132:373–381. DOI: 10.1016/j.talanta.2014.09.017

Huerta, B., Rodriguez-Mozaz, S., Nannou, C., Nakis, L., Ruhí, A., Acuña, V., Sabater, S., Barcelo, D. (2016). Determination of a broad spectrum of pharmaceuticals and endocrine disruptors in biofilm from a waste water treatment plant-impacted river. Science of the Total Environment, 540, 241–249. DOI: 10.1016/j.scitotenv.2015.05.049

Huyghe, E., Matsuda, T.; Thonneau, P. (2003) - Increasing incidence of testicular cancer worldwide: a review. Journal of Urology, 170(1):5–11. DOI: 10.1097/01.ju.0000053866.68623.da

Hwang, C. S.; Kwak, H. S.; Lim, H. J.; Lee, S. H.; Kang, Y. S.; Choe, T. B.; Hur, H. G.; Han, K. O. (2006) - Isoflavone metabolites and their in vitro dual functions: they can act as an estrogenic agonist or antagonist depending on the estrogen concentration. The Journal of Steroid Biochemistry and Molecular Biology, 101(4-5):246–253. DOI: 10.1016/j.jsbmb.2006.06.020

Isidori, M.; Lavorgna, M.; Nardelli, A.; Parrella, A. (2006) - Toxicity on crustaceans and endocrine disrupting activity on Saccharomyces cerevisiae of eight alkylphenols. Chemosphere, 64(1):135-143. DOI: 10.1016/j.chemosphere.2005.10.047

Isobe, T.; Nishiyama, H.; Nakashima, A.; Takada, H. (2001) - Distribution and behavior of nonylphenol, octylphenol, and nonylphenol monoethoxylate in Tokyo metropolitan area: their association with aquatic particles and sedimentary distributions. Environmental Science & Technology, 35(6):1041–1049. DOI: 10.1021/es001250i

Isobe, T.; Serizawa, S.; Horiguchi, T.; Shibata, Y.; Managaki, S.; Takada, H.; Morita, M.; Shiraishi, H. (2006) - Horizontal distribution of steroid estrogens in surface sediments in Tokyo Bay. Environmental Pollution, 144(2):632–638. DOI:10.1016/j.envpol.2006.01.030

Isobe, T.; Takada, H.; Kanai, M. (2007) - Distribution of Polycyclic Aromatic Hydrocarbons (PAHs) and phenolic endocrine disrupting chemicals in South and Southeast Asian mussels. Environmental Monitoring and Assessment, 135:423–440. DOI 10.1007/s10661-007-9661-y

Isolbe, T.; Takada, H.; Kanai, M.; Tsutsumi, S.; Isolbe, K. O.; Boonyatumanond, R.; Zakaria M. P. (2007) - Distribution of polycyclic aromatic hydrocarbons (PAHs) and phenolic endocrine disrupting chemicals in South and Southeast Asian mussels. Environmental Monitoring and Assessment, 135:423-440. DOI: 10.1007/s10661-007-9661-y

Jakimska, A.; Huerta, B.; Barganska, Z.; Kot-Wasik, A.; Rodríguez-Mozaz, S.; Barceló, D. (2013) - Development of a liquid chromatography–tandem mass spectrometry procedure for determination of endocrine disrupting compounds in fish from Mediterranean rivers. Journal of Chromatography A, 1306:44–58. DOI:10.1016/j.chroma.2013.07.050

Jardim, W. F.; Montagner, C. C.; Pescara, I. C.; Umbuzeiro, G. a.; Di Dea Bergamasco, A. M.; Eldridge, M. L.; Sodré, F. F. (2012) - An integrated approach to evaluate emerging contaminants in drinking water. Separation and Purification Technology, 84:3-8. DOI: 10.1016/j.seppur.2011.06.020

Johnson, A. C.; Williams, R. J. (2004) - A model to estimate influent and effluent concentrations of estradiol, estrone, and ethinylestradiol at sewage treatment works. Environmental Science & Technology, 38(13):3649–3658. DOI: 10.1021/es035342u

Jonkers, N.; Laane, R. W. P. M.; De Voogt, P. (2003) - Fate of nonylphenol ethoxylates and their metabolites in two Dutch estuaries: evidence of biodegradation in the field. Environmental Science & Technology, 37(2):321–327. DOI: 10.1021/es020121u

Jonkers, N.; Sousa, A.; Galante-Oliveira, S.; Barroso, C. M.; Kohler, H.-P. E.; Giger, W. (2010) - Occurrence and sources of selected phenolic endocrine disruptors in Ria de Aveiro, Portugal. Environmental Science and Pollution Research, 17(4):834–843. DOI: 10.1007/s11356-009-0275-5

Jouannet, P.; Wang, C.; Eustache, F.; Kold-Jensen, T.; Auger, J. (2001) - Semen quality and male reproductive health: the controversy about human sperm concentration decline. Acta Pathologica Microbiologica et Immunologica Scandinavica, 109(5):333–344. DOI: 10.1111/j.1600-0463.2001.tb05801.x

Kabir, E. R.; Rhamna, M. S.; Rhanman, I. (2015) - A review on endocrine disruptors and their possible impacts on human health. Environmental Toxicology and Pharmacolog, 40:241-258. DOI: 10.1016/j.etap.2015.06.009

Kannan, N.; Yamashita, N.; Petrick, G.; Duinker, J. C. (1998) - Polychlorinated Biphenyls and Nonylphenols in the Sea of Japan. Environmental Science & Technology, 32(12):1747–1753. DOI: 10.1021/es970713q

Kardinaal, A. F. M.; Walkens-Berendsen, D. H.; Arts, C. J. M. (1997) - Pseudo-oestrogens in the diet : Health benefits and safety concerns. Trends in Food Science & Technology, 8(10):327–333. DOI: 10.1016/S0924-2244(97)01070-4

Kester, M. H. A.; Bulduk, S.; Tirboel, D.; Meinl, W.; Glatt, H.; Falany, C. N.; Coughtrie, M. W. H.; Bergman, A.; Safe, S. H.; Kuiper, G. G. J. M.; Schuur, A.G.; Brouwer, A.; Visser, T. J. (2000) - Potent Inhibition of Estrogen Sulfotransferase by Hydroxylated PCB Metabolites: A Novel Pathway Explaining the Estrogenic Activity of PCBs. Endocrinology, 141(5):1897–1900. DOI: 10.1210/endo.141.5.7530

Khim, J. S.; Kannan, K.; Villeneuve, D. L.; Koh, C. H.; Giesy, J. P. (1999) - Characterization and Distribution of Trace Organic Contaminants in Sediment from Masan Bay , Korea: 1. Instrumental Analysis. Environmental Science & Technology, 33(23):4199–4205. DOI: 10.1021/es9904484

Kinani, S.; Bouchonnet, S.; Bourcier, S.; Creusot, N. (2008) - Extraction and purification procedures for simultaneous quantification of phenolic xenoestrogens and steroid estrogens in river sediment by gas chromatography/ion trap mass spectrometry. Rapid Communications in Mass Spectrometry, 22(22):3651–3661. DOI: 10.1002/rcm.3771

Koh, C.-H.; Khim, J. S.; Villeneuve, D. L.; Kannan, K.; Giesy, J. P. (2006) - Characterization of trace organic contaminants in marine sediment from Yeongil Bay, Korea: 1. Instrumental Analyses. Environmental Pollution, 142(1):39–47. DOI: 10.1016/j.envpol.2005.09.005

Koniecko, I.; Staniszewska, M.; Falkowska, L.; Burska, D.; Kielczewska, J.; Jasinska, A. (2014) - Alkylphenols in Surface Sediments of the Gulf of Gdansk (Baltic Sea). Water Air Soil Pollution, 225:2040. DOI 10.1007/s11270-014-2040-8

Körner, W.; Hanf, V.; Schuller, W.; Kempter, C.; Metzger, J.; Hagenmaier, H. (1999) - Development of a sensitive E-screen assay for quantitative analysis of estrogenic activity in municipal sewage plant effluents. Science of the Total Environment, 225(1-2):33–48. DOI: 10.1016/S0048-9697(99)80015-1

Kumar, K. S.; Sajwan, K. S.; Richardson, J. P.; Kannan, K. (2008) - Contamination profiles of heavy metals, organochlorine pesticides, polycyclic aromatic hydrocarbons and alkylphenols in sediment and oyster collected from marsh/estuarine Savannah GA, USA. Marine Pollution Bulletin, 56(1):136–149. DOI: 10.1016/j.marpolbul.2007.08.011

Kurihara, R.; Watanabe, E.; Ueda, Y.; Kakuno, A.; Fujii, K.; Shiraishi, F.; Hashimoto, S. (2007) -Estrogenic activity in sediments contaminated by nonylphenol in Tokyo Bay (Japan) evaluated by vitellogenin induction in male mummichogs (Fundulus heteroclitus). Marine Pollution Bulletin, 54(9):1315–1320. DOI:10.1016/j.marpolbul.2007.06.007

Kuster, M.; Azevedo, D. A.; López De Alda, M. J.; Aquino Neto, F. R.; Barceló, D. (2009) - Analysis of phytoestrogens, progestogens and estrogens in environmental waters from Rio de Janeiro (Brazil). Environment International, 35(7):997–1003. DOI: 10.1016/j.envint.2009.04.006.

Kuster, M.; José López de Alda, M.; Barceló, D. (2004) - Analysis and distribution of estrogens and progestogens in sewage sludge, soils and sediments. Trends in Analytical Chemistry, 23(10–11):790-798. DOI:10.1016/j.trac.2004.08.007.

Labadie, P.; Hill, E. M. (2007) - Analysis of estrogens in river sediments by liquid chromatography–electrospray ionisation mass spectrometry Comparison of tandem mass spectrometry and time-of-flight mass spectrometry. Journal of Chromatography A, 1141(2):174-181. DOI: 10.1016/j.chroma.2006.12.045

Larsen, S. T.; Lund, R. M.; Nielsen, G. D.; Thygesen, P.; Poulsen, O. M. (2002) - Adjuvant effect of di-n-butyl-, di-n-octyl-, di-iso-nonyl- and di-iso-decyl phthalate in a subcutaneous injection model using BALB/c mice. Pharmacology & Toxicology, 91(5):264–272. DOI: 10.1034/j.1600-0773.2002.910508.x

Larsson, D. G. J.; Förlin, L. (2002) - Male-biased sex ratios of fish embryos near a pulp mill: temporary recovery after a short-term shutdown. Environmental Health Perspectives, 110(8):739-42. DOI: 10.1289/ehp.02110739

Lathers, C. M.; (2002) - Educational Issues in Clinical Pharmacology: Who Are Our Audiences and What Are TheirSpecialized Needs? One Specialized Need: “Understanding the Role of Veterinary Medicine in Public Health”. The Journal of Clinical Pharmacology, 42:718-730. DOI: 10.1177/009127002401102669

Laws, S. C.; Carey, S. A.; Ferrell, J. M.; Bodman, G. J.; Cooper, R. L. (2000) - Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats. Toxicological Sciences, 54(1):154–167. DOI: 10.1093/toxsci/54.1.154

Lee, C.-C.; Jiang, L.-Y.; Kuo, Y.-L.; Chen, C.-Y.; Hsieh, C.-Y.; Hung, C.-F.; Tien, C.-J. (2015) - Characteristics of nonylphenol and bisphenol A accumulation by fish and implications for ecological and human health. Science of the Total Environment, 502:417-425. DOI: 10.1016/j.scitotenv.2014.09.042.

Lee, H.-R.; Choi, K.-C. (2013) - 4-tert-Octylphenol stimulates the expression of cathepsins in human breast cancer cells and xenografted breast tumors of a mouse model via an estrogen receptor-mediated signaling pathway. Toxicology, 304:13–20. DOI: 10.1016/j.tox.2012.10.012

Legler, J.; Brouwer, A. (2003) - Are brominated flame retardants endocrine disruptors? Environment International, 29(6):879–885. DOI:10.1016/S0160-4120(03)00104-1

Li, D.; Dong, M.; Shim, W. J.; Hong, S. H.; Oh, J.-R.; Yim, U. H.; Jeung, J. H.; Kanan, N.; Kim, E. S.; Cho, S. R. (2005) - Seasonal and spatial distribution of nonylphenol and IBP in Saemangeum Bay, Korea. Marine Pollution Bulletin, 51(8-12):966–974. DOI: 10.1016/j.marpolbul.2004.11.006

Li, D.; Dong, M.; Shim, W. J.; Yim, U. H.; Hong, S. H.; Kannan, N. (2008) - Distribution characteristics of nonylphenolic chemicals in Masan Bay environments, Korea. Chemosphere, 71(6):1162–1172. DOI: 10.1016/j.chemosphere.2007.10.023

Li, W.C. (2014) - Occurrence, sources, and fate of pharmaceuticals in aquatic environment and soil. Environmental Pollution, 187C:193–201. DOI:10.1016/j.envpol.2014.01.015

Liang, D.-W.; Zhang, T.; Fang, H. H. P.; He, J. (2008) - Phthalates biodegradation in the environment. Applied Microbiology and Biotechnology, 80(2):183–198. DOI: 10.1007/s00253-008-1548-5

Lintelmann, J.; Katayama, A.; Kurihara, N.; Shore, L.; Wenzel, A. (2003) - Endocrine disruptors in the environment (IUPAC Technical Report). Pure and Applied Chemistry, 75(5):631–681. DOI: 10.1351/pac200375050631

Lisboa, N. S.; Fahning, C. S.; Cotrim, G.; Anjos, J. P.; Andrade, J. B.; Hatje, V.; Da Rocha, G. O. (2013) - A simple and sensitive UFLC- fluorescence method for endocrine disrupters determination in marine waters. Talanta, 117:168–175. DOI: 10.1016/j.talanta.2013.08.006

Liu, C.; Kolarik, B.; Gunnarsen, L.; Zhang, Y. (2015). C-Depth Method to Determine Diffusion Coefficient and Partition Coefficient of PCB in Building Materials. Environmental Science & Technology, 49(20):12112–9. DOI:10.1021/acs.est.5b03352

Liu, J.; Wang, R. ; Huang, B.; Lin, C.; Zhou, J.; Pan, X. (2012) - Biological effects and bioaccumulation of steroidal and phenolic endocrine disrupting chemicals in high-back crucian carp exposed to wastewater treatment plant effluents. Environmental Pollution, 162:325-331. DOI:10.1016/j.envpol.2011.11.036

Locatelli, M., Sciascia, F., Cifelli, R., Malatesta, L., Bruni, P., Croce, F. (2016). Analytical methods for the endocrine disruptor compounds determination in environmental water samples. Journal of Chromatography A, 1434:1–18. DOI: 10.1016/j.chroma.2016.01.034

Loos, R.; Wollgast, J.; Castro-Jiménez, J.; Mariani, G.; Huber, T.; Locoro, G.; Hanke, G.; Umlauf, G.; Bidoglio, G.; Hohenblum, P.; Moche, W.; Weiss, S.; Schmid, H.; Leiendecker, F.; Ternes, T.; Ortega, a. N.; Hildebrandt, A.; Barceló, D.; Lepom, P.; Dimitrova, I.; Nitcheva, O.; Polesello, S.; Valsecchi, S.; Boutrup, S.; Sortkjaer, O.; de Boer, R.; Staeb, J. (2008) - Laboratory intercomparison stud for the analysis of nonylphenol and octylphenol in river water. Trends in Analytical Chemistry, 27(1):89-95. DOI: 10.1016/j.trac.2007.10.011

Lu, C. (2009) - Prediction of environmental properties in water-soil-air systems for phthalates. Bulletin of Environmental Contamination and Toxicology, 83(2):168–173. DOI: 10.1007/s00128-009-9728-2

Luzio, A.; Monteiro, S. M.; Rocha, E.; Fontainhas-Fernandes, A. A.; Coimbra, A. M. (2016) - Development and recovery of histopathological alterations in the gonads of zebrafish (Danio rerio) after single and combined exposure to endocrine disruptors (17α-ethinilestradiol and fadrozole). Aquatic Toxicology, 175:90-105.  DOI: 10.1016/j.aquatox.2016.03.014.

Ma, T., Teng, Y., Christie, P., Luo, Y., Chen, Y., Ye, M., Huang, Y. (2013). A new procedure combining GC-MS with accelerated solvent extraction for the analysis of phthalic acid esters in contaminated soils. Frontiers of Environmental Science & Engineering, 7(1):31–42. DOI: 10.1007/s11783-012-0463-2

Mackintosh, C. E.; Maldonado, J. A.; Ikonomou, M. G.; Gobas, F. A. P. C. (2006) - Sorption of phthalate esters and PCBs in a marine ecosystem. Environmental Science & Technology, 40(11):3481–3488. DOI: 10.1021/es0519637

Macon, M. B.; Fenton, S. E. (2013) - Endocrine Disruptors and the Breast: Early Life Effects and Later Life Disease. Journal Mammary Gland Biology and Neoplasia, 18(1):43. DOI: 10.1007/s10911-013-9275-7

Maggioni, S.; Balaguer, P.; Chiozzotto, C.; Benfenati, E. (2013) - Screening of endocrine-disrupting phenols, herbicides, steroid estrogens, and estrogenicity in drinking water from the waterworks of 35 Italian cities and from PET-bottled mineral water. Environmental Science and Pollution Research International, 20(3):1649–1660. DOI: 10.1007/s11356-012-1075-x

Main, K. M.; Skakkebaek; N. E., Virtanen, H. E.; Toppari, J. (2010) - Genital anomalies in boys and the environment. Best Practice & Research. Clinical Endocrinology & Metabolism, 24(2):279–89. DOI:10.1016/j.beem.2009.10.003

Mandich, A.; Bottero, S.; Benfenati, E.; Cevasco, A.; Erratico, C.; Maggioni, S.; Massari, A.; Pedemonte, F.; Viganò, L (2007) - In vivo exposure of carp to graded concentrations of bisphenol A. General and Comparative Endocrinology, 153(1-3):15–24. DOI:10.1016/j.ygcen.2007.01.004

Mankidy, R.; Ranjan, B.; Honaramooz, A.; Giesy, J. P. (2013a) - Effects of novel brominated flame retardants on steroidogenesis in primary porcine testicular cells. Toxicology Letters, 224(13):141–146. DOI: 10.1016/j.toxlet.2013.10.018 Mankidy, R.; Wiseman, S.; Ma, H.; Giesy, J. P. (2013b) - Biological impact of phthalates. Toxicology Letters, 217(1):50–58. DOI: 10.1016/j.toxlet.2012.11.025

Markey, C. M.; Luque, E. H.; Munoz De Toro, M.; Sonnenschein, C.; Soto, A. M. (2001) - In utero exposure to bisphenol A alters the development and tissue organization of the mouse mammary gland. Biology of Reproduction, 65:1215-1223. DOI: 10.1043/0006-363(2001)065<1215:IUETBA>2.0.CO;2

Martino-Andrade, A. J.; Chahoud, I. (2010) - Reproductive toxicity of phthalate esters. Molecular Nutrition & Food Research, 54(1):148–157. DOI: 10.1002/mnfr.200800312

Marx-Stoelting, P’.; Niemann, L.; Ritz, V.; Ulbrich, B.; Gall, A.; Hirsch-Ernst, K. I.; Pfeil, R.; Solecki, R. (2014) - Assessment of three approaches for regulatory decision making on pesticides with endocrine disrupting properties. Regulatory Toxicology and Pharmacology, 70(3):590-604. DOI: 10.1016/j.yrtph.2014.09.001.

Matějíček, D. (2011) - On-line two-dimensional liquid chromatography-tandem mass spectrometric determination of estrogens in sediments. Journal of Chromatography A, 1218(16):2292–2300. DOI: 10.1016/j.chroma.2011.02.041

Melo, S. M.; Brito, N. M. (2014) - Analysis and Occurrence of Endocrine Disruptors in Brazilian Water by HPLC-Fluorescence Detection. Water Air Soil Pollution, 225:1783. DOI: 10.1007/s11270-013-1783-y

Menzies, R.; Quinete, N. S.; Gardinali, P.; Seba, D. (2013) - Baseline occurrence of organochlorine pesticides and other xenobiotics in the marine environment: Caribbean and Pacific collections. Marine Pollution Bulletin, 70(1-2):289–295. DOI: 10.1016/j.marpolbul.2013.03.003

Miège, C.; Peretti, A.; Labadie, P.; Budzinski, H.; Le Bizec, B.; Vorkamp, K.; Tronczynski, J.; Persat, H.; Coquery, M.; Babut, M. (2012) - Occurrence of priority and emerging organic compounds in fishes from the Rhone River (France). Analytical and Bioanalytical Chemistry, 404:2721-2735. DOI: 10.1007/s00216-012-6187-0.

Milligan, S. R.; Balasubramanian, A. V.; Kalita, J. C. (1998) - Relative potency of xenobiotic estrogens in an acute in vivo mammalian assay. Environmental Health Perspective, 106(1): 23–26. DOI: 10.1289/ehp.9810623

Mnif, W.; Hassine, A. I. H.; Bouaziz, A.; Bartegi, A.; Thomas, O.; Roig, B. (2011) - Effect of endocrine disruptor pesticides: A review. International Journal of Environmental Research and Public Health, 8(6):2265–2303. DOI: 10.3390/ijerph8062265

Monteagudo, C.; Mariscal-Arcas, M’; Heras-Gonzalez, L.; Ibanez-Peinado, D.; Rivas, A.; Olea-Serrano, F. (2016) - Effects of maternal diet and environmental exposure to organochlorine pesticides on newborn weight in Southern Spain. Chemosphere, 156:135-142. DOI: 10.1016/j.chemosphere.2016.04.103.

Moss, G. P. (1989) - Nomenclature of steroids. Pure and Applied Chemistry, 61(10):1783–1822. DOI: 10.1351/pac198961101783

Muñoz-de-Toro, M.; Markey, C. M.; Wadia, P. R.; Luque, E. H.; Rubin, B. S.; Sonnenschein, C.; Soto, A. M. (2005) - Perinatal exposure to bisphenol-A alters peripubertal mammary gland development in mice. Endocrinology, 146(9):4138-4147. DOI: 10.1210/en.2005-0340

Nalli, S., Cooper, D. G.; Nicell, J. A. (2002) - Biodegradation of plasticizers by Rhodococcus rhodochrous. Biodegradation, 13(5):343–352. DOI: 10.1023/A:1022313810852

Net, S.; Sempéré, R.; Delmont, A.; Paluselli, A.; Ouddane, B. (2015) - Occurrence, fate, behavior and ecotoxicological state of phthalates in different environmental matrices. Environmental Science & Technology, 49:4019-4035. DOI: 10.1021/es505233b

Noppe, H.; Verslycke, T.; De Wulf, E.; Verheyden, K.; Monteyne, E.; Van Caeter, P.; Janssen, C. R.; De brabanderHubert F. (2007a) - Occurrence of estrogens in the Scheldt estuary: A 2-year survey. Ecotoxicology and Environmental Safety, 66(1):1-8. DOI: 10.1016/j.ecoenv.2006.04.005

Nurulnadia, M. Y.; Koyama, J.; Uno, S.; Kito, A.; Kokushi, E.; Bacolod, E. T.; Ito, K.; Chuman, Y. (2014) - Accumulation of endocrine disrupting chemicals (EDCs) in the polychaete Paraprionospio sp. from the Yodo River mouth, Osaka Bay, Japan. Environmental Monitoring and Assessment, 186(3):1453-1463. DOI: 10.1007/s10661-013-3466-y

Oehlmann, J.; Schulte-Oehlmann, U.; Tillmann, M.; Markert, B. (2000) - Effects of endocrine disruptors on prosobranch snails (Mollusca: Gastropoda) in the laboratory. Part I: Bisphenol A and octylphenol as xeno-estrogens. Ecotoxicology, 9(6):383–397. DOI: 10.1023/A:1008972518019

Ortiz-Zarragoitia, M.; Cajaraville, M. P. (2005) - Effects of selected xenoestrogens on liver peroxisomes, vitellogenin levels and spermatogenic cell proliferation in male zebrafish. Comparative Biochemistry and Physiology, 141(2):133–144. DOI: 10.1016/j.cca.2005.05.010

Ortiz-Zarragoitia, M.; Cajaraville, M.P. (2006) - Biomarkers of exposure and reproduction-related effects in mussels exposed to endocrine disrupters. Archives of Environmental Contamination and Toxicology, 50:361–369. DOI:10.1007/s00244-005-1082-8

Pal, A.; Gin, K. Y.-H.; Lin, A. Y.-C.; Reinhard, M. (2010) - Impacts of emerging organic contaminants on freshwater resources: review of recent occurrences, sources, fate and effects. Science of the Total Environment, 408(24):6062–6069. DOI: 10.1016/j.scitotenv.2010.09.026

Palanza, P.; Nagel, S. C.; Parmigiani, S.; vom Saal, F. S. (2016) - Perinatal exposure to endocrine disruptors: sex, timing and behavioral endpoints. Current Opinion in Behavioral Sciences, 7:69-75. DOI: 10.1016/j.cobeha.2015.11.017.

Panter, G. H.; Thompson, R. S.; Beresford, N.; Sumpter, J. P. (1999) - Transformation of a non-oestrogenic steroid metabolite to an oestrogenically active substance by minimal bacterial activity. Chemosphere, 38(15):3579-3596.
DOI: 10.1016/S0045-6535(98)00572-4

Paoli, D.; Giannandrea, F.; Gallo, M.; Turci, R., Cattaruzza, M. S.; Lombardo, F.; Gandini, L. (2015) - Exposure to polychlorinated biphenyls and hexachlorobenzene, semen quality and testicular cancer risk. Journal of Endocrinological Investigation, 38(7):745–752. DOI:10.1007/s40618-015-0251-5

Paulozzi, L. J. (1999) - International trends in rates of hypospadias and cryptorchidism. Environmental Health Perspectives, 107(4):297–302. DOI: 10.1289/ehp.99107297

Perez, P.; Pulgar, R.; Olea-Serrano, F.; VillaloboS, M.; Rivas, A.; Metzler, M.; Pedraza, V.; Olea, N. (1998) - The estrogenicity of bisphenol A-related diphenylalkanes with various substituents at the central carbon and the hydroxy groups. Environmental Health Perspectives, 106(3):167–174. DOI: 10.1289/ehp.98106167

Pérez-Feás, C.; Barciela-Alonso, M. C.; Bermejo-Barrera, P. (2011) - Presence of phthalates in contact lens and cleaning solutions. Microchemical Journal, 99(1):108-113. DOI: 10.1016/j.microc.2011.04.006

Petrovic, M.; Fernández-Alba, A. R.; Borrull, F.; Marce, R. M.; González, M. E.; Barceló, D. (2002) - Occurrence and distribution of nonionic surfactants, their degradation products, and linear alkylbenzene sulfonates in coastal waters and sediments in Spain. Environmental Toxicology and Chemistry, 21(1):37–46. DOI: 10.1002/etc.5620210106

Picard, K.; Lhuguenot, J. C.; Lavier-Canivenc, M. C.; Chagnon, M. C. (2001) - Estrogenic activity and metabolism of n-butyl benzyl phthalate in vitro: identification of the active molecule(s). Toxicology and Applied Pharmacology, 172(2):108-118. DOI: 10.1006/taap.2001.9141

Pocar, P.; Brevini, T. A. L.; Fischer, B.; Gandolfi, F. (2003) - The impact of endocrine disruptors on oocyte competence. Reproduction, 125(3):313–325. DOI: 10.1530/rep.0.1250313

Pojana, G.; Bonfà, A.; Busetti, F.; Collarin, A.; Marcomini, A. (2004) - Determination of natural and synthetic estrogenic compounds in coastal lagoon waters by HPLC-electrospray-mass spectrometry. International Journal of Environmental Analytical Chemistry, 84(10):717–727.
DOI: 10.1080/03067310410001729060

Pojana, G.; Gomiero, A.; Jonkers, N.; Marcomini, A. (2007) - Natural and synthetic endocrine disrupting compounds (EDCs) in water, sediment and biota of a coastal lagoon. Environment International, 33(7):929–936. DOI: 10.1016/j.envint.2007.05.003

Porte, C.; Janer, G.; Lorusso, L. C.; Ortiz-Zarragoitia, M.; Cajaraville, M. P.; Fossi, M. C.; Canesi, L. (2006) - Endocrine disruptors in marine organisms: approaches and perspectives. Comparative Biochemistry and Physiology, 143(3):303–315. DOI: 10.1016/j.cbpc.2006.03.004

Prins, G. S. (2008) - Endocrine disruptors and prostate cancer risk. Endocrine Related Cancer, 15(3):649–656. DOI: 10.1677/ERC-08-0043

Puy-Azurmendi, E.; Ortiz-Zarragoitia, M.; Kuster, M.; Martínez, E.; Guillamón, M.; Domínguez, C.; Serrano, T.; Barbero, Mari C.; De Alda, M. L.; Bayona, J. M.; Barceló, D.; Cajaraville, M. P. (2010) - An integrated study of endocrine disruptors in sediments and reproduction-related parameters in bivalve molluscs from the Biosphere’s Reserve of Urdaibai (Bay of Biscay). Marine Environmental Research, 69:S63–S66. DOI:10.1016/j.marenvres.2009.10.003

Puy-Azurmendi, E.; Ortiz-Zarragoitia, M.; Villagrasa, M.; Kuster, M.; Aragón, P.; Atienza, J.; Puchades, R.; Maquieira, A.; Domínguez, C.; López De Alda, M.; Fernandes, D.; Porte, C.; Bayona, J. M.; Barceló, D.; Cajaraville, M. P. (2013) - Endocrine disruption in thicklip grey mullet (Chelon labrosus) from the Urdaibai Biosphere Reserve (Bay of Biscay, Southwestern Europe). Science of the Total Environment, 443:233–244. DOI: 10.1016/j.scitotenv.2012.10.078

Quednow, K.; Püttmann, W. (2008) - Endocrine disruptors in freshwater streams of Hesse, Germany: changes in concentration levels in the time span from 2003 to 2005. Environmental Pollution, 152(2):476–483. DOI: 10.1016/j.envpol.2007.05.032 Queiroz, M. E. C.; Lanças, F. M. (2005) - Análise de fármacos em material biológico: acoplamento microextração em fase sólida “no tubo” e cromatografia líquida de alta eficiência. Quimica Nova, 28(5):880-886. DOI: 10.1590/S0100-40422005000500027

Reis Filho, R. W.; Araújo, J. C. de; Vieira, E. M. (2006) - Hormônios sexuais estrógenos: contaminantes bioativos. Quimica Nova, 29(4):817-822. DOI: 10.1590/S0100-40422006000400032.

Renner, R. (1997) - European Bans on Surfactant Trigger Transatlantic Debate. Environmental Science & Technology, 31(7):316–320. DOI: 10.1021/es972366q

Ribeiro, C.; Pardal, M. A.; Martinho, F.; Margalho, R.; Tiritan, M. E.; Rocha, E.; Rocha, M. J. (2009) - Distribution of endocrine disruptors in the Mondego River estuary, Portugal. Environmental Monitoring and Assessment, 149(1-4):183–193. DOI: 10.1007/s10661-008-0192-y

Richardson, S. D. (2002) - Environmental mass spectrometry: emerging contaminants and current issues. Analytical Chemistry, 74(12):2719–2742. DOI: 10.1021/ac020211h

Richardson, S. D. (2012) - Environmental mass spectrometry: emerging contaminants and current issues. Analytical Chemistry, 84(2):747-778. DOI: 10.1021/ac202903d

Richardson, S. D.; Ternes, T. A. (2014) - Water analysis: emerging contaminants and current issues. Analytical Chemistry, 86(6):2813–2848. DOI:10.1021/ac500508t

Richardson, S.; Ternes, T. A. (2011) - Water Analysis: Emerging Contaminants and Current Issues. Analytical Chemistry, 83(12):4614-4648. DOI: 10.1021/ac200915r

Richardson, S.D.; Ternes, T.A. (2015) - Water Analysis: Emerging Contaminants and Current Issues. Analytical Chemistry, 75:3809–3836. DOI:10.1021/ac500508t

Romani, F.; Tropea, A.; Scarinci, E.; Federico, A.; Russo, C. D.; Lisi, L.; Catino, S.; Lanzone, A.; Apa, R. (2014) - Endocrine disruptors and human reproductive failure: the in vitro effect of phthalates on human luteal cells. Fertility and Sterility, 102(3):831-837. DOI: 10.1016/j.fertnstert.2014.05.041

Rubio, S.; Pérez-Bendito, D. (2009) - Recent advances in environmental analysis. Analytical Chemistry, 81(12):4601–4622. DOI: 10.1021/ac900738s

Rudel, R. A.; Camann, D. E.; Spengler, J. D.; Korn, L. R.; Brody, J. G. (2003) - Phthalates, Alkylphenols, Pesticides, Polybrominated Diphenyl Ethers, and Other Endocrine-Disrupting Compounds in Indoor Air and Dust. Environmental Science & Technology, 37(20):4543–4553. DOI: 10.1021/es0264596

Salgueiro-González, N., Turnes-Carou, I., Muniategui-Lorenzo, S., López-Mahía, P., Prada-Rodríguez, D. (2014). Analysis of endocrine disruptor compounds in marine sediments by in cell clean up-pressurized liquid extraction-liquid chromatography tandem mass spectrometry determination. Analytica Chimica Acta, 852:112–120. DOI: 10.1016/j.aca.2014.09.041

Salgueiro-González, N.; Concha-Graña, E.; Turnes-Carou, I.; Muniategui-Lorenzo, S.; López-Mahía, P.; Prada-Rodríguez, D. (2012) - Determination of alkylphenols and bisphenol A in seawater samples by dispersive liquid-liquid microextraction and liquid chromatography tandem mass spectrometry for compliance with environmental quality standards (Directive 2008/105/EC). Journal of Chromatography A, 1223:1–8. DOI: 10.1016/j.chroma.2011.12.011

Salgueiro-González, N.; Turnes-Carou, I.; Besada, V.; Muniategui-Lorenzo, S.; López-Mahía, P.; Prada-Rodríguez, D. (2015) - Occurrence, distribution and bioaccumulation of endocrine disrupting compounds in water, sediment and biota samples from a European river basin. Science of the Total Environment, 529:121–130. DOI:10.1016/j.scitotenv.2015.05.048

Salvador, A.; Moretton, C.; Piram, A.; Faure, R.; (2007) - On-line solid-phase extraction with on-support derivatization for high-sensitivity liquid chromatography tandem mass spectrometry of estrogens in influent/effluent of wastewater treatment plants. Journal of Chromatography A, 1145(1-2):102-109. DOI: 10.1016/j.chroma.2007.01.055

Sánchez-Avila, J.; Fernandez-Sanjuan, M.; Vicente, J.; Lacorte, S. (2011) - Development of a multi-residue method for the determination of organic micropollutants in water, sediment and mussels using gas chromatography-tandem mass spectrometry. Journal of Chromatography A, 1218 (38):6799–6811. DOI: 10.1016/j.chroma.2011.07.056

Santos, A. G.; Regis, A. C. D.; da Rocha, G. O.; Bezerra, M. A.; Jesus, R. M.; de Andrade, J. B. (2016) - A simple, comprehensive, and miniaturized solvent extraction method for determination of particulate-phase polycyclic aromatic compounds in air. Journal of Chromatography A, 1435:6-17. DOI: 10.1016/j.chroma.2016.01.018.

Santos, L. H. M. L. M.; Araújo, A. N.; Fachini, A.; Pena, A.; Delerue-Matos, C.; Montenegro, M. C. B. S. M. (2010) - Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment. Journal of Hazardous Materials, 175(1-3):45–95. DOI: 10.1016/j.jhazmat.2009.10.100

Saravanabhavan, G., Helleur, R.; Hellou, J. (2009) - GC-MS/MS measurement of natural and synthetic estrogens in receiving waters and mussels close to a raw sewage ocean outfall. Chemosphere, 76(8):1156–1162. DOI: 10.1016/j.chemosphere.2009.04.006

Sax, L. (2010) - Polyethylene terephthalate may yield endocrine disruptors. Environmental Health Perspectives, 118(4):445–448. DOI: 10.1289/ehp.0901253

Scheringer, M.; Jones, K. C.; Matthies, M.; Simonich, S.; Van De Meent, D. (2009) - Multimedia partitioning, overall persistence, and long-range transport potential in the context of POPs and PBT chemical assessments. Integrated Environmental Assessment and Management, 5(4):557–576. DOI: 10.1897/IEAM_2009-007.1

Schlenk, D.; Sapozhnikova, Y.; Irwin, M. A.; Xie, L.; Hwang, W.; Reddy, S.; Brownawell, B. J.; Armstrong, J.; Kelly, M.; Montagne, D. E.; Kolodziej, E. P.; Sedlak, D.; Snyder, S. (2005) - In vivo bioassay-guided fractionation of marine sediment extracts from the southern california bight, USA, for estrogenic activity. Environmental Toxicology and Chemistry, 24(11):2820–2826. DOI: 10.1897/05-116R.1

Selvaraj, K. K.; Shanmugam, G.; Sampath, S.; Larsson, D. G. J.; Ramaswamy, B. R. (2014) - GC-MS determination of bisphenol A and alkylphenol ethoxylates in river water from India and their ecotoxicological risk assessment. Ecotoxicology and Environmental Safety, 99:13–20. DOI: 10.1016/j.ecoenv.2013.09.006

Shan, X. M.; Shen, D. H.; Wang, B. S.; Lu, B. B.; Huang, F. Y. (2014) - Simultaneous determination of bisphenols and alkylphenols in water by solid phase extraction and ultra performance liquid chromatography-tandem mass spectrometry. Biomedical and Environmental Sciences, 27(6):471–4. DOI:10.3967/bes2014.076

Shang, D. Y.; Macdonald, R. W.; Ikonomou, M. G. (1999) - Persistence of Nonylphenol Ethoxylate Surfactants and Their Primary Degradation Products in Sediments from near a Municipal Outfall in the Strait of Georgia, British Columbia, Canada. Environmental Science & Technology, 33(9):1366–1372. DOI: 10.1021/es980966z

Shi, J.; Liu, X.; Chen, Q.; Zhang, H. (2014) - Spatial and seasonal distributions of estrogens and bisphenol A in the Yangtze River Estuary and the adjacent East China Sea. Chemosphere 111:336–343. DOI: 10.1016/j.chemosphere.2014.04.046

Shimada, K.; Mitamura, K.; Higashi, T. (2001) - Gas chromatography and high-performance liquid chromatography of natural steroids. Journal of Chromatography A, 935(1-2):141–172. DOI: 10.1016/S0021-9673(01)00943-8

Soares, A.; Guieysse, B.; Jefferson, B.; Cartmell, E.; Lester, J. N. (2008) - Nonylphenol in the environment: a critical review on occurrence, fate, toxicity and treatment in wastewaters. Environment International, 34(7):1033–1049. DOI: 10.1016/j.envint.2008.01.004

Solé, M.; Alda, M. J. L.; Castillo, M.; Porte, C.; Ladegaard-Pedersen, K.; Barceló, D. (2000) - Estrogenicity Determination in Sewage Treatment Plants and Surface Waters from the Catalonian Area (NE Spain). Environmental Science & Technology, 34(24):5076–5083. DOI: 10.1021/es991335n

Soto, A M.; Justicia, H.; Wray, J. W.; Sonnenschein, C. (1991) - p-Nonyl-phenol: an estrogenic xenobiotic released from “modified” polystyrene. Environ Health Perspect, 92:167–173. DOI: 10.2307/3431154

Soto, A. M.; Sonnenschein, C.; Chung, K. L.; Fernandez, M. F.; Olea, N.; Serrano, F. O. (1995) - The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants. Environmental Health Perspectives, 103(7):113–122. DOI: 10.2307/3432519

Staniszewska, M.; Koniecko, I.; Falkowska, L.; Krzymyk, E. (2015) - Occurrence and distribution of bisphenol A and alkylphenols in the water of the gulf of Gdansk (Southern Baltic). Marine Pollution Bulletin, 91(1):372–379. DOI: 10.1016/j.marpolbul.2014.11.027

Stewart, M.; Olsen, G.; Hickey, C. W.; Ferreira, B.; Jelić, A.; Petrović, M.; Barcelo, D. (2014) - A survey of emerging contaminants in the estuarine receiving environment around Auckland, New Zealand. Science of the Total Environment. 468–469:202–210. DOI: 10.1016/j.scitotenv.2013.08.039

Sumpter, J. P. (1998) - Xenoendorine disrupters environmental impacts. Toxicology Letters, 102-103:337–342. DOI: 10.1016/S0378-4274(98)00328-2

Sun, K.; Jin, J.; Gao, B.; Zhang, Z.; Wang, Z.; Pan, Z.; Xu, D.; Zhao, Y. (2012) - Sorption of 17α-ethinyl estradiol, bisphenol A and phenanthrene to different size fractions of soil and sediment. Chemosphere, 88(5):577–583. DOI: 10.1016/j.chemosphere.2012.03.034

Sun, L.; Zang, S. Y.; Sun, H. J. (2014). Sources and history of PAHs in lake sediments from oil-producing and industrial areas, northeast China. International Journal of Environmental Science and Technology, 11(7):2051–2060. DOI:10.1007/s13762-013-0396-8

Sutton, R.; Sedlak, M. D.; Yee, D.; Davis, A. J.; Crane, D.; Grace, R. (2014) - Declines in Polybrominated Diphenyl Ether Contamination of San Francisco Bay following Production Phase-Outs and Bans. Environmental Science & Techinology, 49(2):777-84. DOI:10.1021/es503727b.

Talsness, C. E.; Andrade, A. J. M.; Kuriyama, S. N.; Taylor, J. A.; Vom Saal, F. S. (2009) - Components of plastic: experimental studies in animals and relevance for human health. Philosophical Transactions of the Royal Society B, 364(1526):2079–2096. DOI: 10.1098/rstb.2008.0281

Tan, B. L. L.; Hawker, D. W.; Müller, J. F.; Leusch, F. D. L.; Tremblay, L. A.; Chapman, H. F. (2007a) - Modelling of the fate of selected endocrine disruptors in a municipal wastewater treatment plant in South East Queensland, Australia. Chemosphere, 69(4):644–654. DOI: 10.1016/j.chemosphere.2007.02.057

Tan, B. L. L.; Hawker, D.W.; Müller, J. F.; Leusch, F. D. L.; Tremblay, L. A.; Chapman, H. F. (2007b) - Comprehensive study of endocrine disrupting compounds using grab and passive sampling at selected wastewater treatment plants in South East Queensland, Australia. Environment International, 33(5):654–669. DOI: 10.1016/j.envint.2007.01.008

Tata, J. R. (2005) - One hundred years of hormones. European Molecular Biology Organization, 6(6):490–496, 2005. DOI: 10.1038/sj.embor.7400444

Thibaut, R.; Porte, C. (2004) - Effects of endocrine disrupters on sex steroid synthesis and metabolism pathways in fish. The Journal of Steroid Biochemistry and Molecular Biology, 92(5):485–494. DOI: 10.1016/j.jsbmb.2004.10.008

Thorup, J.; Nordenskjöld, A.; Hutson, J. M. (2014) - Genetic and environmental origins of hypospadias. Current Opinion in Endocrinology, Diabetes, and Obesity, 21(3):227–32. DOI:10.1097/MED.0000000000000063

Toppari, J., Kaleva, M.; Virtanen, H. E. (2001) - Trends in the incidence of cryptorchidism and hypospadias, and methodological limitations of registry-based data. Human Reproduction Update, 7(3):282-286. DOI: 10.1093/humupd/7.3.282

Torres, N. H., Aguiar, M. M., Ferreira, L. F. R., Américo, J. H. P., Machado, Â. M., Cavalcanti, E. B., Tornisielo, V. L. (2015). Detection of hormones in surface and drinking water in Brazil by LC-ESI-MS/MS and ecotoxicological assessment with Daphnia magna. Environmental Monitoring and Assessment, 187:379. DOI: 10.1007/s10661-015-4626-z

Trachsel, M. (2008) - Results of the Consensus Platforms: Positions and Recommendations Derived from Scientific Findings in a Joint Effort of Academics, Industry, and Authorities. Chimia, 62(5):432-438. DOI: 10.2533/chimia.2008.432

Tsai, Y.-A.; Lin, C;-L.; Hou, J.-W.; Huang, P.-C.; Lee, M.-C.; Chen, B.-H.; Wu, M.-T.; Chen, C.-C.; Wang, S.-L.; Lee, C.-C.; Hsiung, C. A.; Chen, M.-L. (2016) - Effects of high di(2-ethylhexyl)phthalate (DEHP) exposure due to tainted food intake on pre-pubertal growth characteristics in a Taiwanese population. Environmental Research, 149:197-205. DOI: 10.1016/j.envres.2016.05.005.

Tsuda, T.; Takino, A.; Kojima, M.; Harada, H.; Muraki, K.; Tsuji, M. (2000) - 4-Nonylphenols and 4-tert-octylphenol in water and fish from rivers flowing into Lake Biwa. Chemosphere, 41(5):757–762. DOI: 10.1016/S0045-6535(99)00465-8

Valdés, M. E., Marino, D. J., Wunderlin, D. A. Somoza, G. M. Ronco, A. E. Carriquiriborde, P. (2015). Screening concentration of E1, E2 and EE2 in sewage effluents and surface waters of the “Pampas” region and the “Rio de la Plata” estuary (Argentina). Bulletin of Environmental Contamination and Toxicology, 94(1):29–33. DOI: 10.1007/s00128-014-1417-0

Valton, A. S.; Serre-Dargnat, C.; Blanchard, M.; Alliot, F.; Chevreuil, M.; Teil, M. J. (2014) - Determination of Phthalates and Their by-Products in Tissues of Roach (Rutilus Rutilus) from the Orge River (France). Environmental Science and Pollution Research, 21:12723–12730. DOI: 10.1007/s11356-014-3213-0

Vandenberg, L. N.; Chahoud, I.; Heindel, J. J.; Padmanabhan, V.; Paumgartten, F. J. R.; Schoenfelder, G. (2010) - Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A. Environmental Health Perspectives, 118(8):1055–1070. DOI: 10.1289/ehp.0901716

Vandenberg, L. N.; Maffini, M. V.; Wadia, P. R.; Sonnenschein, C.; Rubin, B. S.; Soto, A. M. (2007) - Exposure to environmentally relevant doses of the xenoestrogen bisphenol-A alters development of the fetal mouse mammary gland. Endocrinology, 148(1):116–127. DOI: 10.1210/en.2006-0561

Vandenberg, L. N.; Schaeberle, C. M.; Rubin, B. S.; Sonnenschein, C.; Soto, A. M. (2013) - The male mammary gland: a target for the xenoestrogen bisphenol A. Reproductive Toxicology, 37:15–23. DOI: 10.1016/j.reprotox.2013.01.002

Vega-Morales, T.; Sosa-Ferrera, Z.; Santana-Rodríguez, J. J. (2013). Evaluation of the presence of endocrine-disrupting compounds in dissolved and solid wastewater treatment plant samples of Gran Canaria Island (Spain). BioMed Research International, 2013:1-15. DOI: 10.1155/2013/790570

Vekey, K. (2001) - Mass spectrometry and mass-selective detection in chromatography. Journal of Chromatography A, 921(2):227-236. DOI: 10.1016/S0021-9673(01)00825-1

Ventura, C.; Nieto, M. R. R.; Bourguignon, N.; Lux-Santos, V.; Rodriguez, H.; Cao, G.; Randi, A.; Nuñez, M. (2016) - Pesticides chlorpyrifos acts as an endocrine disruptor in adult rats causing changes in mammary glands and hormonal balance. The Journal of Steroid Biochemistry and Molecular Biology, 156:1-9.  DOI: 10.1016/j.jsbmb.2015.10.010.

Vidal-Dorsch, D. E.; Bay, S. M.; Maruya, K.; Snyder, S. A.; Trenholm, R. A.; Vanderford, B. J. (2012) - Contaminants of emerging concern in municipal wastewater effluents and marine receiving water. Environmental Toxicology and Chemistry, 31(12):2674–2682. DOI: 10.1002/etc.2004

Villar-Navarro, M.; Ramos-Payán, M.; Fernández-Torres, R.; Callejón-Mochón, M.; Bello-López, M. Á. (2013) - A novel application of three phase hollow fiber based liquid phase microextraction (HF-LPME) for the HPLC determination of two endocrine disrupting compounds (EDCs), n-octylphenol and n-nonylphenol, in environmental waters. Science of The Total Environment, 443:1-6. DOI: 10.1016/j.scitotenv.2012.10.071

Volkova, K., Caspillo, N. R., Porseryd, T., Hallgren, S., DinnÉtz, P., Porsch-Hällström, I. (2015). Developmental exposure of zebrafish (Danio rerio) to 17α-ethinylestradiol affects non-reproductive behavior and fertility as adults, and increases anxiety in unexposed progeny. Hormones and Behavior, 73:30–38. DOI: 10.1016/j.yhbeh.2015.05.014

Vos, J. G.; Becher, G.; van den Berg, M.; de Boer, J.; Leonards, P. E. G. (2003) - Brominated flame retardants and endocrine disruption. Pure and Applied Chemistry, 75(11-12):2039-2046. DOI: 10.1351/pac200375112039

Wang, J.; Shim, W.; Yim, U.; Kannan, N.; Li, D. (2010) - Nonylphenol in bivalves and sediments in the northeast coast of China. Journal of Environmental Sciences, 22(11):1735–1740. DOI: 10.1016/S1001-0742(09)60313-2

Wang, W.; Meng, B.; Lu, X.; Liu, Y.; Tao, S. (2007) - Extraction of polycyclic aromatic hydrocarbons and organochlorine pesticides from soils: a comparison between Soxhlet extraction, microwave-assisted extraction and accelerated solvent extraction techniques. Analytica Chimica Acta, 602(2):211-222. DOI: 10.1016/j.aca.2007.09.023

Weiss, J. M.; Hamers, T.; Thomas, K. V.; Van Der Linden, S.; Leonards, P. E. G.; Lamoree, M. H. (2009) - Masking effect of anti-androgens on androgenic activity in European river sediment unveiled by effect-directed analysis. Analytical and Bioanalytical Chemistry, 394(5):1385–1397.DOI: 10.1007/s00216-009-2807-8

WHO. State of the Science of Endocrine Disrupting Chemicals. (United Nations Environment Programme), 2012, 30p.

Wu, J.; Zhang, L.; Yang, Z. (2010) - A Review on the Analysis of Emerging Contaminants in Aquatic Environment. Critical Reviews in Analytical Chemistry, 40(4):234-245. DOI: 10.1080/10408347.2010.515467

Xie, Z.; Ebinghaus, R.; Temme, C.; Lohmann, R.; Caba, A.; Ruck, W. (2007) - Occurrence and air-sea exchange of phthalates in the Arctic. Environmental Science & Technology, 41(13):4555–4560. DOI: 10.1021/es0630240

Xie, Z.; Lakaschus, S.; Ebinghaus, R.; Caba, A.; Ruck, W. (2006) - Atmospheric concentrations and airesea exchanges of nonylphenol , tertiary octylphenol and nonylphenol monoethoxylate in the North Sea. Environmental Pollution, 142(1):170–180. DOI: 10.1016/j.envpol.2005.08.073

Xu, E. G. B.; Morton, B.; Lee, J. H.W.; Leung, K. M.Y. (2015) - Environmental fate and ecological risks of nonylphenols and bisphenol A in the Cape D’Aguilar Marine Reserve, Hong Kong. Marine Pollution Bulletin, 91(1):128–138. DOI: 10.1016/j.marpolbul.2014.12.017

Xu, N.; Xu, Y.-F.; Xu, S.; Li, J.; Tao, H.-C. (2012) - Removal of estrogens in municipal wastewater treatment plants: a Chinese perspective. Environmental Pollution, 165:215–224. DOI: 10.1016/j.envpol.2011.12.025

Xu, W.; Yan, W.; Huang,W.; Miao, L.; Zhong, L. (2014) - Endocrine-disrupting chemicals in the Pearl River Delta and coastal environment: sources, transfer, and implications. Environmental Geochemistry and Health, 36(6):1095–1104. DOI: 10.1007/s10653-014-9618-3

Xu, X.; Roman, J. M.; Issaq, H. J.; Keefer, L. K.; Veenstra, T. D.; Ziegler, R. G. (2007) - Quantitative Measurement of Endogenous Estrogens and Estrogen Metabolites in Human Serum by Liquid Chromatography-Tandem Mass Spectrometry. Analytical Chemistry, 79(20):7813-7821. DOI: 10.1021/ac070494j

Xu, X.; Veenstra, T. D.; Fox, S. D.; Roman, J. M.; Issaq, H. J.; Falk, R.; Saavedra, J. E.; Keefer, L. K.; Ziegler, R. G. (2005) - Measuring Fifteen Endogenous Estrogens Simultaneously in Human Urine by High-Performance Liquid Chromatography-Mass Spectrometry. Analytical Chemistry, 77 (20):6646-6654. DOI: 10.1021/ac050697c

Yan, H.; Wang, H. (2013) - Recent development and applications of dispersive liquid–liquid microextraction. Journal of Chromatography A, 1295:1-15. DOI: 10.1016/j.chroma.2013.04.053

Yi, B.; Kim, C.; Yang, M. (2010) - Biological monitoring of bisphenol A with HLPC/FLD and LC/MS/MS assays. Journal of Chromatography B, 878(27):2606–2610. DOI: 10.1016/j.jchromb.2010.02.008

Ying, G.-G., Williams, B.; Kookana, R. (2002a) - Environmental fate of alkylphenols and alkylphenol ethoxylates--a review. Environment International, 28(3):215–226. DOI:10.1016/S0160-4120(02)00017-X

Ying, G.-G.; Kookana, R. S.; Ru, Y.-J. (2002b) - Occurrence and fate of hormone steroids in the environment. Environment International, 28(6):545–551. DOI: 10.1016/S0160-4120(02)00075-2

Yu, Y.; Huang, Q.; Cui, J.; Zhang, K.; Tang, C.; Peng, X. (2011) - Determination of pharmaceuticals, steroid hormones, and endocrine-disrupting personal care products in sewage sludge by ultra-high-performance liquid chromatography – tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 399(2):891–902. DOI:  10.1007/s00216-010-4295-2

Zhang, J.; Yang, M.; Zhang, Y.; Chen, M. (2008) - Biotransformation of nonylphenol ethoxylates during sewage treatment under anaerobic and aerobic conditions. Journal of Environmental Sciences, 20(2):135–141. DOI: 10.1016/S1001-0742(08)60021-2

Zhang, S.; You, J.; Sun, Z.; Song, C.; Ning, S.; Zhao, C.; Suo, Y. (2012) - A sensitive method for extraction and determination of endocrine-disrupting compounds from wastewater using 10-ethyl-acridone-2-sulfonyl chloride as pre-column labeling reagent by high-performance liquid chromatography with fluorescence detection. Microchemical Journal, 103:90–96, 2012. DOI: 10.1016/j.microc.2012.01.009

Zhang, X.; Li, Q.; Li, G.; Wang, Z.; Yan, C. (2009) - Levels of estrogenic compounds in Xiamen Bay sediment, China. Marine Pollution Bulletin, 58(8):1210–1216. DOI: 10.1016/j.marpolbul.2009.03.011.

Zhang, Y.; Cao, Y.; Jiang, X.; Zhao, Y.; Fang, X., Xie, C. (2015) - Could exposure to phthalates speed up or delay pubertal onset and development? A 1.5-year follow-up of a school-base population. Environment International, 83:41-49.  DOI: 10.1016/j.envint.2015.06.005.

Zhang, Z.; Ren, N.; Kannan, K.; Nan, J.; Liu, L.; Ma, W.; Qi, H.; Li, Y. (2014) - Occurrence of Endocrine-Disrupting Phenols and Estrogens in Water and Sediment of the Songhua River, Northeastern China. Archives of Environmental Contamination and Toxicology, 66(3):361-369. DOI: 10.1007/s00244-014-9998-5

Zheng, W.; Li, X.; Yates, S. R.; Bradford, S. A. (2012) - Anaerobic transformation kinetics and mechanism of steroid estrogenic hormones in dairy lagoon water. Environmental Science & Technology, 46:5471–5478. DOI: 10.1021/es301551h

Zrafi-Nouira, I.; Safi, N. M. D.; Bahri, R.; Mzoughi, N.; Aissi, A.; Abdennebi, H. B. E. N.; Saidane-Mosbahi, D. (2010) - Distribution and Sources of Polycyclic Aromatic Hydrocarbons Around a Petroleum Refinery Rejection Area in Jarzouna-Bizerte (Coastal Tunisia). Soil and Sediment Contamination, 19(3):292–306. DOI: 10.1080/15320381003695223

Zuloaga, O.; Nvarro, P.; Bizkarguenaga, E.; Iparraguirre, A.; Vallejo, A.; Olivares, M.; Prieto, A. (2012) - Overview of extraction, clean-up and detection techniques for the determination of organic pollutants in sewage sludge: A review. Analytica Chimica Acta, 736:7-29. DOI: 10.1080/15320381003695223

Zuo, Y.; Zhang, K.; Deng, Y. (2006) - Occurrence and photochemical degradation of 17alpha-ethinylestradiol in Acushnet River Estuary. Chemosphere, 63(9):1583–1590. DOI: 10.1016/j.chemosphere.2005.08.063

Zuo, Y.; Zhang, K.; Lin, Y. (2007) - Microwave-accelerated derivatization for the simultaneous gas chromatographic-mass spectrometric analysis of natural and synthetic estrogenic steroids. Journal of Chromatography A, 1148(2):211–218. DOI: 10.1016/j.chroma.2007.03.037


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